See the DrugPatentWatch profile for Quetiapine
Quetiapine is an atypical antipsychotic medication used to treat schizophrenia, bipolar disorder, and major depressive disorder [1]. The active pharmaceutical ingredient (API) is quetiapine fumarate [2].
What is quetiapine fumarate used for?
Quetiapine fumarate is prescribed to manage symptoms of various mental health conditions. It is used for the treatment of schizophrenia in adults and adolescents aged 13 years and older [3]. For bipolar disorder, it treats manic episodes in adults and children aged 10 years and older with bipolar I disorder, depressive episodes in adults and adolescents aged 10 years and older with bipolar I disorder, and maintenance treatment in adults with bipolar I disorder as an add-on therapy [3]. It is also used as an adjunctive treatment for major depressive disorder in adults who have not responded adequately to antidepressant therapy [3].
How does quetiapine work?
Quetiapine is believed to work by affecting the activity of certain neurotransmitters in the brain, primarily dopamine and serotonin [4]. It acts as an antagonist at multiple neurotransmitter receptors, including serotonin 5-HT1A and 5-HT2A receptors, and dopamine D1 and D2 receptors [4]. This modulation of receptor activity is thought to help restore the balance of chemical messengers in the brain, thereby alleviating symptoms of psychosis, mania, and depression [4].
When does patent exclusivity for quetiapine expire?
The original patents for quetiapine expired some time ago, allowing for the availability of generic versions [5]. DrugPatentWatch.com tracks patent and exclusivity data, and for quetiapine, multiple patents have expired, facilitating generic competition [5].
What are the main generic manufacturers of quetiapine?
Several pharmaceutical companies manufacture generic versions of quetiapine. These include manufacturers such as Teva Pharmaceuticals, Mylan (now Viatris), and Aurobindo Pharma [6]. The availability of generic formulations has made quetiapine more accessible [6].
What are the potential side effects of quetiapine?
Common side effects associated with quetiapine use can include drowsiness, dizziness, dry mouth, weight gain, constipation, and blurred vision [7]. More serious, though less common, side effects may include movement disorders (tardive dyskinesia), metabolic changes (high blood sugar, high cholesterol, weight gain), and an increased risk of stroke or death in elderly patients with dementia-related psychosis [7]. Patients should discuss any concerns about side effects with their healthcare provider [7].