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What is diclofenac?

See the DrugPatentWatch profile for diclofenac

Diclofenac is a non‑steroidal anti‑inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It’s commonly found in both prescription and over‑the‑counter formulations, most often as a topical gel, patch, or oral tablet.


Key points

Feature Details
Drug class NSAID (non‑steroidal anti‑inflammatory)
Mechanism of action Inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, reducing production of prostaglandins that mediate pain, swelling, and fever.
Common indications • Acute pain (e.g., muscle aches, dental pain)
• Osteoarthritis, rheumatoid arthritis
• Menstrual cramps
• Post‑operative pain
• Topical use for localized pain and inflammation (e.g., tendonitis, sprains)
Typical doses • Oral tablets: 25–75 mg two to three times daily, not to exceed 150 mg/day
• Topical gel/patch: applied per package instructions (usually 2–4 g of gel to affected area, 2–4 times per day)
Common side effects • GI upset, heartburn, nausea
• Headache, dizziness
• Increased blood pressure (especially with prolonged use)
• Rare but serious: stomach ulcers, bleeding, kidney impairment, allergic reactions
Precautions • Use lowest effective dose for the shortest possible time.
• Avoid if you have peptic ulcer disease, severe heart disease, kidney problems, or are taking other NSAIDs.
• Consult your doctor before using during pregnancy or while breastfeeding.
Drug interactions • Anticoagulants (e.g., warfarin) can increase bleeding risk.
• Other NSAIDs, steroids, or antihypertensives can augment GI or cardiovascular side effects.
• Certain blood pressure medications may lose effectiveness.
Contraindications • Known hypersensitivity to diclofenac or other NSAIDs
• Active gastrointestinal bleeding or ulceration
• Severe heart failure, uncontrolled hypertension, or severe renal/hepatic impairment

Quick FAQ

  • Is diclofenac safe for everyone?
    No. People with a history of ulcers, heart disease, kidney problems, or severe liver disease should avoid it or use under strict medical supervision.

  • Can it be used during pregnancy?
    Generally, diclofenac is avoided in the third trimester because of the risk of premature closure of the ductus arteriosus in the fetus. Use only if a doctor deems the benefit outweighs the risk.

  • How long can I take it?
    Short‑term use (days to a few weeks) is typical. Long‑term use should be monitored by a healthcare provider to watch for GI, kidney, or cardiovascular complications.

  • What’s the difference between oral and topical diclofenac?
    Oral tablets are systemic, affecting the whole body, while topical formulations deliver the drug directly to a specific area, generally producing fewer systemic side effects.


Bottom line: Diclofenac is a versatile NSAID for pain and inflammation, but it must be used with caution, especially if you have underlying health conditions or are on other medications. Always follow your prescribing information or a healthcare professional’s guidance.



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