Yes, Advil (ibuprofen) can interact with certain antidepressants, specifically Selective Serotonin Reuptake Inhibitors (SSRIs) [2][3]. This interaction can lead to an increased risk of bleeding, stomach ulcers, and a condition called serotonin syndrome [2][3]. Serotonin syndrome is a potentially life-threatening condition that occurs when the body has too much serotonin, a neurotransmitter, due to the interaction of certain medications [2].

The risk of this interaction is generally low, but it can be managed by closely monitoring the patient's medication and symptoms [3]. Healthcare providers should be aware of this potential interaction and may need to adjust the dosage or change the medication regimen accordingly [2].

Patients should inform their healthcare providers about all the medications they are taking, including over-the-counter drugs like Advil, to prevent potential drug interactions [3]. They should also be aware of the symptoms of serotonin syndrome, such as agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, heavy sweating, and diarrhea [2].

In summary, Advil can interact with certain antidepressants, leading to an increased risk of bleeding, stomach ulcers, and serotonin syndrome. This risk can be managed through careful monitoring and appropriate adjustments to the medication regimen.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/ADVIL>
[2] <https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/considerations/>
[3] <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298645/>