The ivermectin formulations that do not contain polysorbate 80 are typically the veterinary-use oral pastes and injectable solutions, as well as the topical creams and lotions intended for human use [1]. In contrast, some of the oral tablet formulations of ivermectin intended for human use may contain polysorbate 80 as an excipient [1].
Why is Polysorbate 80 in Some Ivermectin Products?
Polysorbate 80 is an emulsifier and surfactant that helps to dissolve ivermectin, which is poorly soluble in water, and stabilize the formulation [2]. This allows for consistent dosing and absorption of the active ingredient in oral and topical preparations [2].
What Ivermectin Products Contain Polysorbate 80?
Oral tablet formulations of ivermectin intended for human use may contain polysorbate 80 to aid in the dissolution and absorption of the drug [1]. Examples include prescription ivermectin for conditions like onchocerciasis and strongyloidiasis [1].
Which Ivermectin Products Avoid Polysorbate 80?
Many ivermectin products, particularly those formulated for veterinary use such as oral pastes and injectables, and topical human formulations like creams and lotions, do not list polysorbate 80 as an ingredient [1]. These formulations may use alternative methods to deliver the active ingredient [1].
Where Can I Find Ingredient Information for Ivermectin?
Ingredient information for ivermectin products can be found on the product packaging, in the prescribing information or package insert, and through pharmaceutical databases [1]. DrugPatentWatch.com provides information on drug formulations and patents, which can sometimes include details about excipients [3].