Aspirin is a common medication used for various purposes, including pain relief, fever reduction, and blood-thinning. It is also commonly prescribed for patients with a history of heart disease or stroke to reduce the risk of future events. While aspirin has proven to be effective in many cases, there are some potential long-term effects to consider.

One of the most significant risks associated with long-term aspirin use is gastrointestinal bleeding [3]. Aspirin can cause irritation and damage to the stomach lining, leading to ulcers and bleeding. This risk is higher in older adults and those with a history of stomach ulcers or bleeding disorders. In rare cases, aspirin can also cause bleeding in the brain, which can be life-threatening [2].

Another potential long-term effect of aspirin use is kidney damage. Prolonged use of aspirin can lead to chronic kidney disease and even kidney failure in some cases [3]. This risk is higher in patients with pre-existing kidney problems or those taking other medications that can damage the kidneys.

Finally, long-term aspirin use can also increase the risk of Reye's syndrome in children and teenagers. This rare but potentially fatal condition causes swelling in the liver and brain and can lead to seizures, coma, and even death [2].

In conclusion, while aspirin is generally safe and effective when used as directed, there are some potential long-term effects to consider. These include gastrointestinal bleeding, kidney damage, and an increased risk of Reye's syndrome in children and teenagers. Patients should always consult with their healthcare provider before starting any new medication, including aspirin.

Sources:
[2] Mayo Clinic. (2021). Daily aspirin therapy: Understand the benefits and risks. https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin-therapy/art-20046797
[3] National Center for Biotechnology Information. (2011). Aspirin: pharmacology and clinical applications. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086018/
[1] Drug Patent Watch. (2021). Aspirin. https://www.drugpatentwatch.com/p/tradename/ASPIRIN