What is mefenamic acid (and what is it used for)?
Mefenamic acid (often just called mefenamic) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat short-term pain. It’s commonly used for painful conditions such as menstrual (period) pain (dysmenorrhea), and it can also be used for other types of mild to moderate pain when an NSAID is appropriate.
How does mefenamic work?
Like other NSAIDs, mefenamic acid reduces pain and inflammation by blocking enzymes involved in making prostaglandins (cyclooxygenase/COX pathways). Prostaglandins are chemicals that contribute to pain, swelling, and inflammation.
How is mefenamic usually taken?
Dosing depends on the indication and the specific product (immediate-release vs other formulations) and should follow the label or clinician instructions. Many NSAID products are taken after food to reduce stomach irritation.
What side effects are most common with mefenamic?
Common NSAID-related side effects include stomach discomfort or indigestion. Serious NSAID risks can include:
- Stomach or intestinal bleeding/ulcers
- Kidney problems (especially in people with dehydration, kidney disease, or who use certain medicines)
- Increased cardiovascular risk in some patients
- Allergic reactions (including asthma flare in some NSAID-sensitive people)
If you have a history of ulcers/GI bleeding, kidney disease, or NSAID allergy, mefenamic may not be suitable without medical guidance.
Who should avoid or use extra caution?
Extra caution is typically needed if you:
- Have a history of stomach ulcers or GI bleeding
- Have kidney disease or are dehydrated
- Have heart disease or high cardiovascular risk
- Take blood thinners or other medicines that raise bleeding risk
- Are pregnant (NSAIDs are often avoided around later pregnancy stages)
- Use other NSAIDs at the same time
Drug interactions to watch for
Mefenamic acid can interact with other medications commonly associated with increased bleeding or kidney stress, including:
- Anticoagulants/antiplatelet drugs (bleeding risk)
- Other NSAIDs (higher GI and kidney risk)
- Certain blood pressure medicines and diuretics (possible kidney effects in some patients)
- Lithium or methotrexate (NSAID effects can raise levels)
Check your medication list with a pharmacist or clinician.
Is mefenamic the same as mefenamic acid?
Yes. “Mefenamic” typically refers to mefenamic acid. Product names and strengths vary by country and manufacturer.
Where can I check detailed dosing and safety info by country?
If you tell me your country (and the strength on the package, like 250 mg or 500 mg), I can help you interpret the label instructions and typical guidance for that exact product format.
Sources: None (no provided source material to cite).