The generic version of Januvia is called sitagliptin [1].
When Can Sitagliptin Become Available?
The original patent for Januvia (sitagliptin) expired in October 2022 [1]. This means generic versions, like sitagliptin, are now available [1].
What is Januvia Used For?
Januvia is a prescription medication used to treat type 2 diabetes [2]. It belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors [3]. Sitagliptin works by increasing levels of incretins, which are natural substances that help regulate blood sugar levels [3]. It is often used in combination with diet and exercise, or with other diabetes medications [2].
How Does Sitagliptin Work?
Sitagliptin works by inhibiting the DPP-4 enzyme [3]. This enzyme normally breaks down incretin hormones like GLP-1 and GIP. By inhibiting DPP-4, sitagliptin increases the active levels of these incretins, which then stimulate the pancreas to release more insulin and reduce the liver's production of sugar [3].
What Are the Risks Associated with Sitagliptin?
Like other DPP-4 inhibitors, sitagliptin carries potential risks. These include a risk of developing severe and sometimes disabling joint pain [4]. It may also cause pancreatitis, an inflammation of the pancreas [5]. Patients have also raised concerns about potential side effects such as headaches, stuffy or runny nose, and sore throat [6].
How Does Sitagliptin Compare to Other Diabetes Medications?
Sitagliptin is a DPP-4 inhibitor. Other classes of diabetes medications include metformin, sulfonylureas, SGLT2 inhibitors, and GLP-1 receptor agonists. Each class works through different mechanisms to lower blood sugar and has a distinct profile of benefits and risks [7].
Who Manufactures Generic Sitagliptin?
Following the patent expiry, several pharmaceutical companies have begun manufacturing and marketing generic versions of sitagliptin [1].
Sources:
1. DrugPatentWatch.com
2. National Institute of Diabetes and Digestive and Kidney Diseases
3. U.S. Food & Drug Administration
4. U.S. Food & Drug Administration
5. U.S. Food & Drug Administration
6. WebMD
7. Centers for Disease Control and Prevention