How does lipitor lower lipid levels?

Lipitor lowers lipid levels by blocking HMG-CoA reductase, the enzyme that controls cholesterol production in the liver. This process slows cholesterol synthesis and triggers the liver to pull LDL cholesterol from the blood.

How does this action affect LDL receptors?

Lipitor's inhibition of HMG-CoA reductase increases the number of LDL receptors on liver cells. These receptors bind and clear LDL particles from the bloodstream, lowering circulating LDL levels by 20-60% depending on dose.

What changes occur in triglyceride levels?

Lipitor also lowers triglycerides modestly, usually by 10-30%, often through indirect effects on VLDL production. Patients with hypertriglyceridemia may see larger reductions.

Can Lipitor raise HDL cholesterol?

Lipitor raises HDL by 5-15% in many patients. This small increase occurs alongside the primary LDL-lowering effect and does not drive the main benefits of therapy.

When does the Wirkung begin to show?

Lipitor reaches peak plasma concentration after 1-2 hours and achieves maximum lipid-lowering effect after 4-6 weeks of continuous use.