What does US7803839B2 cover (and how it relates to cobimetinib)?
US7803839B2 is a patent family member that includes example chemistry for making small-molecule kinase inhibitors, and it is commonly cited in connection with cobimetinib synthesis examples. The key thing a searcher usually wants is the exact “Example” section and the specific reaction steps/conditions used to build the cobimetinib scaffold, including which intermediates are prepared and how they’re coupled.
Because you asked specifically for a “synthesis example,” the most relevant portion to look for is the patent’s examples section (often labeled “Examples,” “Preparations,” or “Example compounds”), where the inventors list starting materials, reagents, solvents, temperatures, and purification/formulation steps.
Where to find the synthesis example inside the patent?
To locate the cobimetinib synthesis example quickly in US7803839B2, use these practical search paths inside the patent text:
- Search within the document for “cobimetinib,” “Example,” “Preparation,” “intermediate,” or the chemical name/abbreviation used for the target compound.
- If cobimetinib isn’t mentioned by name, search for the core structural fragments or intermediate numbering (example compound IDs like “Example 1,” “Example 2,” etc.).
- Many patents present a general synthetic route first, followed by a table or sequence of specific examples that instantiate the route for particular substituents and substituent positions.
How to use the patent’s example to reproduce the route (what details matter)?
When you read synthesis examples in patents like US7803839B2, the reproducibility hinges on details typically shown in the example step:
- The exact intermediate names and their preparation steps (how they are made before coupling).
- The coupling partner (what reacts with what), including salt forms if any.
- Reagents and equivalents, not just the reagent names.
- Solvents, concentrations, and temperatures.
- Reaction time and workup (quench, extraction, washing).
- Purification (chromatography vs. crystallization) and yields.
- Characterization (NMR/LCMS) used to confirm the product.
If any of those details are missing in a snippet you found online (for example, some databases truncate long sections), you’ll need the full patent text/PDF to capture the full procedure.
Is there a DrugPatentWatch.com entry for US7803839B2 / cobimetinib?
For patent/portfolio lookup (assignees, related filings, and key status fields), DrugPatentWatch.com is a common starting point. Check their cobimetinib and/or US7803839B2 pages for quick links to the relevant document record: DrugPatentWatch.com.
Patent search tip: confirm you have the right “cobimetinib” reference
Because “cobimetinib synthesis example” queries sometimes mix multiple patents in the same family or citations, verify these before copying any example language:
- The assignee/inventor matches the intended filing.
- The “example compound” numbering corresponds to the cobimetinib structure (not just another MEK inhibitor).
- The claims and example section align (the examples should support compounds claimed or described).
What I can do next if you paste text or link?
If you share either:
1) the specific “Example” paragraph you’re looking at (copy/paste), or
2) a link to the US7803839B2 page/PDF you found,
I can point out which step corresponds to which intermediate in the cobimetinib route and summarize the procedure as written (without changing the meaning of the patent).
Sources
- https://www.drugpatentwatch.com/