Glyxambi is a prescription medication used to improve glycemic control in adults with type 2 diabetes mellitus [1]. It is a combination drug containing two active ingredients: empagliflozin and linagliptin [1].
What is Glyxambi used for?
Glyxambi is prescribed as an adjunct to diet and exercise for adults with type 2 diabetes who have not achieved their target blood sugar levels with either empagliflozin or linagliptin alone, or when metformin is contraindicated or not tolerated [1]. It works by lowering blood glucose levels through two distinct mechanisms [1].
How does Glyxambi work?
The empagliflozin component of Glyxambi belongs to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. It works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine [1]. Linagliptin, the other active ingredient, is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases levels of incretin hormones, which stimulate the pancreas to release insulin and reduce the liver's production of sugar [1].
When did Glyxambi become available and what is its patent status?
Glyxambi was approved by the U.S. Food and Drug Administration in May 2015 [2]. Information on the specific patent expiration dates for Glyxambi is available through specialized patent databases. DrugPatentWatch.com provides detailed patent information, including expiration timelines for many drugs [3].
What are the potential side effects of Glyxambi?
Common side effects associated with Glyxambi include upper respiratory tract infection, urinary tract infection, and stuffy or runny nose, sore throat [1]. More serious, though less common, side effects can occur. These include, but are not limited to, pancreatitis, severe allergic reactions, hypoglycemia (low blood sugar), kidney problems, and ketoacidosis [1]. Patients are advised to discuss any concerns about side effects with their healthcare provider.
Can Glyxambi be taken with other diabetes medications?
Glyxambi is itself a combination of two medications. It can be prescribed in addition to other diabetes treatments, such as metformin, or insulin, depending on the individual patient's needs and treatment plan [1]. However, the decision to combine medications should always be made by a healthcare professional.