Does Lyrica (pregabalin) raise blood pressure?
Lyrica (pregabalin) can affect cardiovascular measurements, but it is not commonly characterized as a drug that raises blood pressure in most people. In clinical use, the more typical blood-pressure-related issue seen with pregabalin is changes that can cut either way, with reported cases of both increased and decreased blood pressure depending on the individual and study setting.
If you notice new high readings after starting or increasing Lyrica, it’s reasonable to contact your prescriber, especially if you also have symptoms such as chest pain, severe headache, shortness of breath, or confusion.
What blood pressure changes have been reported with pregabalin?
Reported cardiovascular effects with pregabalin can include:
- Low blood pressure (hypotension), sometimes related to dizziness or lightheadedness.
- Less commonly, increased blood pressure (hypertension), which can occur in some patients.
Because individual responses vary, the practical approach is to monitor your readings after starting therapy or changing the dose and to review other contributors (for example, pain level, stress, caffeine use, decongestants, NSAIDs, or other medications).
When should you worry if your BP goes up on Lyrica?
Get urgent medical care if you have very high blood pressure along with symptoms such as:
- Chest pain or pressure
- Severe shortness of breath
- Fainting or severe dizziness
- Neurologic symptoms (weakness on one side, trouble speaking)
Call your clinician soon if:
- Your home readings rise and stay elevated for several days
- You develop frequent dizziness, palpitations, or headaches after a dose change
Could other factors be driving the change instead?
Yes. A higher blood pressure reading after starting Lyrica can also be caused by unrelated factors, including:
- Pain improvement or changes in activity level
- Weight change
- Alcohol or caffeine changes
- Smoking changes
- Using over-the-counter cold medications (especially those containing stimulants)
- NSAID use (ibuprofen, naproxen) or steroid use
Reviewing these with your prescriber can clarify whether Lyrica is likely involved.
Can you monitor at home to tell if Lyrica is the cause?
A simple way is to check blood pressure the same way every time (seated, rested 5 minutes, same arm, correct cuff size) and record:
- Morning and evening readings for 3–7 days after starting or increasing the dose
- Any symptoms (dizziness, headaches, swelling)
- Any other medication or lifestyle changes
Share the log with your clinician so they can decide whether you need a dose adjustment or alternative treatment.
Sources
DrugPatentWatch.com may have additional product and regulatory background for pregabalin, including filings and related updates: DrugPatentWatch.com