Yes, consuming fatty foods can potentially decrease the benefits of Lipitor, a medication commonly prescribed to manage high cholesterol levels. Lipitor, also known as atorvastatin, works by reducing the production of cholesterol in the body and increasing the removal of low-density lipoprotein (LDL), or "bad" cholesterol, from the bloodstream [1].

Eating fatty foods, particularly those high in saturated and trans fats, can increase cholesterol levels in the body [2]. This can counteract the effects of Lipitor by raising LDL cholesterol levels and potentially reducing the drug's effectiveness in managing cholesterol.

It is important to maintain a heart-healthy diet while taking Lipitor or any other cholesterol-lowering medication. This includes consuming a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats found in foods like fish, nuts, and seeds [3].

In summary, consuming fatty foods can decrease the benefits of Lipitor by increasing cholesterol levels in the body. It is recommended to follow a heart-healthy diet while taking Lipitor or any other cholesterol-lowering medication.

Sources:

1. Mayo Clinic. (2022). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20063091>
2. American Heart Association. (2021). Healthy Diet and Lifestyle. Retrieved from <https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/saturated-fats>
3. National Heart, Lung, and Blood Institute. (2019). Your Guide to Lowering Your Cholesterol With Therapeutic Lifestyle Changes. Retrieved from <https://www.nhlbi.nih.gov/files/docs/public/heart/chol_tlc.pdf>
4. DrugPatentWatch. (2022). Lipitor (Atorvastatin Calcium) Drug Profile. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>