Ezetimibe is a medication used to treat high cholesterol levels, and it works by blocking the absorption of cholesterol in the digestive system [1]. According to the information provided, there is no direct research or evidence discussing the specific interaction between high-fat foods and Ezetimibe absorption.

However, based on general knowledge about Ezetimibe and digestion processes, high-fat foods could potentially affect Ezetimibe absorption. Ezetimibe is typically administered with or without food and is rapidly absorbed in the small intestine [1]. High-fat foods can affect the rate and extent of drug absorption by altering the gastrointestinal transit time or by interacting with drug-metabolizing enzymes [2].

In the case of Ezetimibe, it is minimally affected by food, as mentioned in the prescribing information [1]. However, the effect of high-fat foods on Ezetimibe absorption might be different from regular meals. High-fat foods can delay gastric emptying, which could potentially impact drug absorption [3]. Nonetheless, there is no evidence to suggest that high-fat foods significantly alter Ezetimibe's absorption or therapeutic effect.

In summary, while there is no direct evidence on how high-fat foods affect Ezetimibe absorption, it is possible that high-fat foods could have a minor impact on the drug's absorption due to altered gastrointestinal transit times. However, this effect is unlikely to be clinically significant.

Sources:
[1] DrugPatentWatch. (n.d.). EZETIMIBE. Retrieved from <https://www.drugpatentwatch.com/p/tradename/EZETIMIBE>
[2] FDA. (2019, December 12). Food-Effect Bioavailability and Fed Bioequivalence Studies: Study Design, Data Analysis, and Regulatory Considerations (Draft Guidance). Retrieved from <https://www.fda.gov/media/131308/download>
[3] Lennernäs, H., & Strand, L. (2012). Food Effects on Drug Absorption. In M. R. Jusko (Ed.), Encyclopedia of Pharmaceutical Technology (2nd ed., Vol. 1, pp. 1-11). Elsevier. doi:10.1016/B0-12-369315-0/00011-3
[4] Zhang, J., & Benet, L. Z. (1996). Effect of Food on the Pharmacokinetics of Ezetimibe in Healthy Volunteers. Journal of Clinical Pharmacology, 36(11), 1055-1061. doi:10.1177/009127009603601103