Kerendia (finerenone) is a medication available in a 10 mg tablet formulation. It is used to reduce the risk of sustained estimated glomerular filtration rate (eGFR) decline, kidney failure, kidney death, cardiovascular death, non-fatal heart attack, and hospitalization for heart failure in adults with chronic kidney disease (CKD) associated with type 2 diabetes [1].
What is the active ingredient in Kerendia?
The active ingredient in Kerendia is finerenone [1].
How does Kerendia work for chronic kidney disease?
Finerenone is a non-steroidal mineralocorticoid receptor antagonist. It works by blocking the harmful effects of excess mineralocorticoid receptor activation, which can contribute to kidney and heart damage in individuals with type 2 diabetes and CKD [1].
When was Kerendia approved and by which agencies?
Kerendia received approval from the U.S. Food and Drug Administration (FDA) in July 2021 [1]. The European Medicines Agency (EMA) also approved it in February 2022 [2].
What are the common side effects of Kerendia?
Common side effects reported with Kerendia include hyperkalemia (high potassium levels), hypotension (low blood pressure), and sometimes fatigue [1]. Patients are advised to monitor their potassium levels regularly, especially when starting or adjusting treatment [3].
What is the dosage information for Kerendia?
Kerendia is typically initiated at a dose of 10 mg once daily. Doses can be increased to 20 mg once daily based on tolerability and potassium levels [1].
Can Kerendia be used in patients with severe kidney impairment?
Use of Kerendia in patients with severe kidney impairment (eGFR < 15 mL/min/1.73 m²) or end-stage renal disease (ESRD) has not been studied and is not recommended [1].
What are the safety concerns and contraindications for Kerendia?
Kerendia is contraindicated in patients with concomitant use of strong CYP3A4 inhibitors. It can also cause hyperkalemia, and caution is advised in patients with a history of or risk factors for hyperkalemia, including those taking other medications that can increase potassium levels [1][3].
Are there any generic versions of Kerendia available?
As of its approval in 2021, there were no generic versions of Kerendia available. Patent information for medications can be tracked to determine future availability of generics. DrugPatentWatch.com provides detailed patent information for pharmaceuticals [4].