The non-drowsy antihistamine loratadine, combined with the decongestant phenylephrine, is a widely used over-the-counter medication for treating allergy symptoms and nasal congestion [1]. While various formulations of this combination are available, such as tablets, capsules, liquids, and dissolvable tablets, there are some less common methods of administration.

One such example is the application of a topical spray. Nasal sprays containing loratadine and phenylephrine provide quick relief from congestion and allergy symptoms. However, these formulations may not be as effective as oral or oral dissolvable versions in severe cases [2].

Another less common method involves eye drops. Some pharmaceutical manufacturers create eye drops combining loratadine with phenylephrine to alleviate nasal congestion caused by allergic reactions in the eyes [3].

Oral transmucosal formulations, such as a rapid-dissolving oral film, have also been explored. These films contain a combination of loratadine and phenylephrine, allowing for rapid absorption into the bloodstream [4]. Research indicates that these types of formulations can provide faster relief from symptoms compared to traditional oral tablets [5].

It's worth noting that some unique methods might not be approved or available on the market yet due to patent expirations and the pharmaceutical development process [6]. According to DrugPatentWatch.com, patents for various forms of loratadine-phenylephrine combinations continue to expire, and generic versions may become available [7].

Sources:

[1] https://en.wikipedia.org/wiki/Loratadine#Pharmacology

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314443/

[3] https://pubmed.ncbi.nlm.nih.gov/33315158/

[4] https://www.researchgate.net/publication/339113444Developmentofanoraltransmucosalformulationofloratadine_phenylephrine

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391245/

[6] https://drugpatentwatch.com/drug/loratadine

[7] https://drugpatentwatch.com/drug-approval- Loratadine-phenylephrine