There is no direct evidence that avocado oil affects the effectiveness of Lipitor. However, it is important to be aware of potential food-drug interactions. Lipitor (atorvastatin) is a statin drug used to lower cholesterol levels in the blood [1]. According to a study published in the Journal of Clinical Lipidology, consuming avocados can help lower LDL (bad) cholesterol levels in adults who are overweight or obese [2]. However, this study did not investigate any interactions between avocado oil and Lipitor.

According to Stat News, grapefruit and grapefruit juice can interfere with the metabolism of Lipitor, leading to an increase in its concentration in the blood and potentially increasing the risk of side effects [3]. This is because grapefruit contains compounds that inhibit the enzyme responsible for breaking down Lipitor in the liver.

It is always recommended to talk to a healthcare provider before making any significant changes to your diet or medication regimen. They can provide personalized advice on potential food-drug interactions and help ensure the safe and effective use of medications.

Sources:
[1] DrugPatentWatch. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Wang, L., Bordi, P. L., Fleming, J. A., Hill, A. M., Kris-Etherton, P. M. (2015). Effect of a moderate fat diet with and without avocados on lipoprotein particle number, size and subclasses in overweight and obese adults: A randomized, controlled trial. Journal of Clinical Lipidology, 9(3), 345-353. doi: 10.1016/j.jacl.2015.03.011
[3] Stat News. (2016, November 3). Medications and food: What to know before you dig in. Retrieved from https://www.statnews.com/2016/11/03/medications-food-drug-interactions/