After analyzing the provided sources, there is no indication that Vascepa (icosapent ethyl) can affect alcohol tolerance.

Vascepa is a prescription medication used to treat high triglyceride levels in adults. It contains a high concentration of eicosapentaenoic acid (EPA), which is an omega-3 fatty acid found in fish oil. [1]

According to Healthline, there are no known interactions between Vascepa and alcohol. However, it is important to note that excessive alcohol consumption can increase triglyceride levels and potentially counteract the benefits of taking Vascepa. [2]

Additionally, UpToDate mentions that lifestyle modifications, such as limiting alcohol intake, are recommended for managing hypertriglyceridemia. [3]

In conclusion, there is no evidence to suggest that Vascepa affects alcohol tolerance. However, excessive alcohol consumption can increase triglyceride levels and potentially counteract the benefits of taking Vascepa. It is important to consult with a healthcare provider regarding any concerns about alcohol consumption while taking Vascepa.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.healthline.com/health/drugs/vascepa
[3] https://www.uptodate.com/contents/hypertriglyceridemia-in-adults-management