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See the DrugPatentWatch profile for Terbinafine
Terbinafine tablets are a systemic antifungal. They are mainly used to treat fungal infections of the skin and nails caused by dermatophytes. Common uses (indications) - Onychomycosis (fungal infection of the toenails or fingernails) - Tinea infections of the skin: tinea pedis (athlete’s foot), tinea cruris (jock itch), and tinea corporis (ringworm) How it works - Terbinafine inhibits fungal squalene epoxidase, disrupting ergosterol production and killing the fungus. Typical dosing (adult, general guidelines) - Nail infections: - Toenails: usually 250 mg once daily for about 12 weeks - Fingernails: usually 250 mg once daily for about 6 weeks - Skin infections (tinea corporis/cruris/pedis): commonly 250 mg once daily for 2–6 weeks, depending on the site and severity Note: Your specific duration may differ; a clinician will tailor it to your infection and response. Administration tips - Take with food or a meal containing fat to improve absorption - Full course is important even if symptoms improve earlier Important safety information - Liver safety: can affect liver function; baseline liver tests are often done, and continuing therapy may require monitoring. Stop and seek care if you develop jaundice (yellowing of eyes/skin), dark urine, severe fatigue, or abdominal pain. - Side effects: upset stomach, headache, rash, loss of taste or altered sense of smell (usually reversible) - Not for everyone: avoid in severe liver disease; use with caution in pregnancy or breastfeeding (discuss with a clinician) - Interactions: terbinafine can inhibit CYP2D6 and may interact with drugs metabolized by that route (e.g., certain antidepressants, beta-blockers, etc.). It may affect other liver-metabolized drugs as well. Tell your doctor about all medicines you take. Who should not use it or needs caution - Significant liver disease - Known hypersensitivity to terbinafine - Pregnancy or breastfeeding: consult a clinician If you’re asking about a specific infection, body site, or your location (which can affect exact dosing), tell me and I’ll tailor the information.
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