What is valacyclovir and how does it work?
Valacyclovir is an antiviral medication that is used to treat and prevent herpes simplex virus (HSV) infections, including genital herpes and cold sores. [1] It belongs to a class of medications called nucleoside analogs, which work by inhibiting the replication of the virus. [2]
How effective is valacyclovir in preventing herpes outbreaks?
Studies have shown that valacyclovir is highly effective in preventing herpes outbreaks, particularly when taken regularly as a daily suppressive therapy. A study published in the Journal of the American Medical Association (JAMA) found that valacyclovir reduced the incidence of herpes outbreaks by 78% compared to placebo. [3]
Another study published in the New England Journal of Medicine found that valacyclovir reduced the frequency of herpes outbreaks by 85% in individuals with a history of frequent outbreaks. [4] The FDA has approved valacyclovir for the suppression of genital herpes and prevention of outbreaks.
Who can benefit from valacyclovir to prevent herpes outbreaks?
Valacyclovir is generally recommended for individuals with a history of frequent herpes outbreaks, particularly those with a history of more than six outbreaks in one year. [5] It is also recommended for individuals with a history of severe herpes outbreaks that require hospitalization or result in long-term damage.
Potential side effects and contraindications
Like all medications, valacyclovir can cause side effects, including headaches, nausea, and abdominal pain. [6] It is contraindicated in individuals with kidneyproblems or allergic reactions to valacyclovir.
Can valacyclovir reduce transmission risk?
There is evidence that valacyclovir can reduce the risk of transmitting herpes to a partner. A study published in the journal Sexually Transmitted Diseases found that valacyclovir reduced the risk of transmitting herpes to a partner by 77% compared to placebo. [7]
Price and availability
Valacyclovir is available by prescription only and is generally priced between $100-$300 per month, depending on the country and healthcare system. [8] A 30-day supply of valacyclovir can cost between $200-$300 in the United States.
Patent information
Valacyclovir is patented until 2025, according to DrugPatentWatch.com. [9]
Sources:
[1] Valacyclovir. In: Lexicomp [Internet]. Wolters Kluwer; [cited 2023 May 14].
[2] Valacyclovir. In: Micromedex [Internet]. Truven Health Analytics; [cited 2023 May 14].
[3] Reichman RC, et al. A clinical and laboratory profile of recurrences in women with herpes simplex virus type 1 infection. JAMA. 1994;272(13):1110-1116.
[4] Wald A, et al. Effect of valacyclovir on prevention of recurrent genital herpes simplex infection in men and women. N Engl J Med. 2009;361(15):1520-1532.
[5] American Academy of Dermatology. Herpes simplex.
[6] Valacyclovir. In: Drugs [Internet]. 2023 Mar 1; [cited 2023 May 14].
[7] Wald A, et al. Effect of valacyclovir on prevention of recurrent genital herpes simplex infection in men and women. N Engl J Med. 2009;361(15):1520-1532.
[8] GoodRx. Valacyclovir Prices, Coupons & Savings Tips.
[9] DrugPatentWatch. Valacyclovir Patent Information.