Recommended Starting Dose for Ozempic
Ozempic (semaglutide) starts at 0.25 mg injected subcutaneously once weekly for the first 4 weeks. This low dose helps patients adjust and reduces gastrointestinal side effects like nausea.[1]
How to Increase the Dose
After 4 weeks, increase to 0.5 mg weekly. If needed for better blood sugar control, doctors may raise it to 1 mg weekly after at least 4 more weeks, or up to 2 mg weekly after another 4 weeks. Always follow your doctor's guidance—doses aren't one-size-fits-all.[1][2]
Why Start Low?
The 0.25 mg initiation minimizes common early side effects. Skipping it or ramping up too fast raises nausea, vomiting, or diarrhea risks. Studies show gradual titration improves tolerability.[1]
Who Sets the Dose?
Healthcare providers tailor it based on type 2 diabetes control, kidney function, and response. It's not for weight loss alone unless prescribed off-label; Wegovy uses higher semaglutide doses for obesity.[2]
Missed Dose Instructions
If you miss a dose, take it within 5 days. Otherwise, skip and resume the next weekly dose. Don't double up.[1]
Storage and Administration Tips
Store pens in the fridge (36-46°F); unrefrigerated in-use pens last 56 days at room temperature. Inject into thigh, abdomen, or upper arm—rotate sites. No shaking needed.[1]
[1]: Ozempic Prescribing Information (Novo Nordisk)
[2]: FDA Label for Ozempic