See the DrugPatentWatch profile for edex
How to Use EDEX (Alprostadil Injection)
EDEX is an injectable form of alprostadil used to treat erectile dysfunction by injecting it directly into the penis. It causes blood vessels to widen, leading to an erection. Always follow your doctor's instructions exactly, as improper use can cause serious injury like prolonged erection (priapism) or scarring. Do not self-medicate.
Standard Dosing and Preparation
Start with the lowest dose your doctor prescribes, typically 1.25 to 2.5 micrograms (mcg) of alprostadil, though it can go up to 40 mcg based on response. Each EDEX cartridge mixes with bacteriostatic water to create a solution.
1. Wash hands and work surface.
2. Snap off the cartridge cap and insert into the sterile diluent vial.
3. Swirl gently (do not shake) until dissolved—solution should be clear.
4. Withdraw the dose into a syringe using a 1/2-inch, 27- to 30-gauge needle.[1][2]
Injection Technique
Inject into the side of the penis (not the top, bottom, or head) at a 90-degree angle. Rotate sites to avoid irritation.
1. Clean injection site with alcohol swab.
2. Hold penis upright with non-dominant hand; stretch skin taut.
3. Insert needle fully and inject slowly over 5-10 seconds.
4. Withdraw needle and apply pressure for 5 minutes to stop bleeding.
5. Dispose of needle in sharps container.
Erection starts in 5-20 minutes and lasts 30-60 minutes. Intercourse can occur anytime during this window. Use no more than 3 times per week, with 24 hours between doses.[1][2]
What If the Erection Lasts Too Long?
If erection exceeds 4 hours, seek emergency care immediately—priapism requires urgent treatment to prevent permanent damage.[1]
Common Mistakes and Risks
- Wrong site: Causes pain or penile fracture.
- Too high dose: Leads to priapism or hypotension.
- Dirty technique: Infection risk.
Side effects include penile pain (common), bruising, swelling, or dizziness. Rare: fibrosis or curved erection with overuse. Stop use if these occur and tell your doctor.[2]
Storage and Expiration
Store unopened cartridges at room temperature (up to 25°C/77°F). Once mixed, use within 24 hours; refrigerate unused portion up to 24 hours. Check for patent expiry or generics on DrugPatentWatch.com for supply info.[3][1]
Who Shouldn't Use It?
Avoid if you have sickle cell disease, blood disorders, penile implants, or allergies to alprostadil. Not for women or under 18. Inform doctor of heart issues, as it can drop blood pressure.[2]
Consult prescribing info or your pharmacist for full details. EDEX is prescription-only.
Sources
[1] EDEX Prescribing Information (FDA-approved label)
[2] Drugs.com - EDEX Dosage Guide
[3] DrugPatentWatch.com - EDEX Patents