Aripiprazole half life?

Question

Accepted Answer

For the oral form: the elimination half-life of aripiprazole is about 75 hours (roughly 3 days). The active metabolite dehydro-aripiprazole has a longer half-life of about 94 hours.
Implication: it takes roughly 1–2 weeks to reach steady-state with regular dosing (about 5 half-lives).
For other factors: half-lives can vary with age, liver function, and drug interactions (aripiprazole is metabolized mainly by CYP2D6 and CYP3A4).
For the long-acting injectable (depot) form: it produces a slow, extended release, so the apparent elimination is longer due to the depot; exact half-life numbers are not the same as the oral form.

If you want, tell me whether you’re asking about the oral form or a specific formulation, and I can tailor the numbers.

Ask Questions, Get Industry Insights … Instantly