Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body. The drug works by inhibiting an enzyme called HMG-CoA reductase, which is involved in the production of cholesterol in the liver [1].

According to a study published in the Journal of Clinical Lipidology, consumption of citrus fruits may enhance the cholesterol-lowering effects of atorvastatin [2]. The study found that patients who consumed citrus fruits along with atorvastatin had significantly lower levels of LDL cholesterol (the "bad" cholesterol) compared to those who only took atorvastatin. The researchers suggest that the flavonoids present in citrus fruits may have a synergistic effect with atorvastatin, enhancing its cholesterol-lowering properties.

Another study published in the Journal of Food and Drug Analysis investigated the effects of grapefruit juice on atorvastatin pharmacokinetics (how the drug is absorbed, distributed, metabolized, and eliminated in the body) [3]. The study found that grapefruit juice can increase the absorption of atorvastatin, leading to higher blood levels of the drug. However, the study also notes that this can increase the risk of adverse effects, such as muscle pain and liver damage, which are known side effects of atorvastatin.

In summary, consuming citrus fruits may enhance the cholesterol-lowering effects of atorvastatin, while grapefruit juice may increase the absorption of the drug and its associated side effects. Patients should talk to their healthcare provider before making any changes to their medication or diet.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497409/
[3] https://pubmed.ncbi.nlm.nih.gov/24239156/