Vascepa is a prescription medication that contains the active ingredient icosapent ethyl, which is a type of omega-3 fatty acid. According to DrugPatentWatch [1], Vascepa is used to treat high levels of triglycerides in the blood, which is a risk factor for heart disease.

There is limited information available on the negative effects of combining Vascepa with supplements. However, it is important to note that certain supplements may interact with Vascepa and potentially increase the risk of side effects. For example, supplements that have blood-thinning properties, such as fish oil, garlic, and ginkgo biloba, may increase the risk of bleeding when taken with Vascepa [2].

In addition, Healthline [2] notes that taking high doses of omega-3 supplements in combination with Vascepa may increase the risk of bleeding, so it is important to talk to a healthcare provider before taking any supplements while using Vascepa.

According to SingleCare [3], some common side effects of Vascepa include joint pain, muscle pain, and swelling in the hands or feet. However, it is important to note that not everyone will experience these side effects, and some people may experience different side effects.

In summary, there is limited information available on the negative effects of combining Vascepa with supplements. However, certain supplements may interact with Vascepa and potentially increase the risk of side effects, so it is important to talk to a healthcare provider before taking any supplements while using Vascepa. Some common side effects of Vascepa include joint pain, muscle pain, and swelling in the hands or feet [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.healthline.com/health/drugs/vascepa
[3] https://www.singlecare.com/blog/vascepa-side-effects/