Do you mean the active pharmaceutical ingredient (API) piroxicam, or something else (e.g., a product name, a supplier, or a data sheet)? Here’s a concise overview of piroxicam as an API, plus what I can help with next.
What is piroxicam API?
- A non-steroidal anti-inflammatory drug (NSAID) of the oxicam class.
- Used as the active pharmaceutical ingredient in various inflammatory pain medications (e.g., for osteoarthritis and rheumatoid arthritis).
- Mechanism: non-selective inhibition of COX enzymes, yielding anti-inflammatory and analgesic effects.
- Typical properties (high-level):
- Molecular weight around 331 g/mol (formula roughly C15H13N3O4S).
- Generally administered in oral dosage forms (e.g., 20 mg capsules in finished products); the API itself is manufactured to pharmaceutical-grade standards.
- Long elimination half-life (roughly on the order of 50 hours, with variability among individuals).
- Poor water solubility; high plasma protein binding.
Regulatory/safety notes (high level)
- Associated risks: gastrointestinal ulcers/bleeding, renal effects, and rare severe skin reactions; caution or avoidance in patients with high GI risk, active ulcers, significant hepatic/renal impairment, or in pregnancy.
- Often not first-line due to safety concerns; many guidelines prefer shorter half-life NSAIDs with more favorable safety profiles.
- If you’re sourcing API for formulation, you’ll typically specify pharmacopeial grade (USP/EP/BP) and appropriate certificates of analysis, not just technical grade.
What you might want next (tell me which applies):
- Data/specs: I can provide a draft API specification (assay, impurities, residual solvents, heavy metals, water content, identification tests, etc.) aligned with USP/EP/JP or your in-house standard.
- Regulatory/regional info: I can summarize status in specific regions (e.g., US, EU, others) and any notable safety labeling or restrictions.
- Sourcing: I can help you prepare an RFQ or supplier checklist, including required documents (CoA, stability data, batch size, packaging standards, supplier capabilities, GxP compliance, etc.).
- Identification data: I can fetch or provide CAS number, PubChem CID, and IUPAC name if you need precise identifiers for procurement or documentation.
- Technical data sheet: I can assemble a concise datasheet outline you can share with suppliers (quality specs, packaging, storage, handling, safety measures).
If you want, tell me:
- Which country/region you’re sourcing for (US, EU, etc.).
- Grade needed (USP/EP/BP pharmacopeial API vs. technical grade).
- Any specific specs or documents you require (CoA format, stability data, impurity limits).
- Whether you want supplier recommendations or a draft RFQ.
I can tailor the information or draft a production-ready spec/RFQ for you.