Darolutamide cause diarrhea in adults?

What are the common side effects of Darolutamide in adults?

Darolutamide, a non-steroidal anti-androgen, is approved for the treatment of non-metastatic castration-resistant prostate cancer (nmCRPC). While generally well-tolerated, diarrhea can be a side effect of Darolutamide in some adults [1].

Who is at higher risk of experiencing diarrhea with Darolutamide?

Clinical trials have demonstrated that diarrhea can occur in up to 14% of patients taking Darolutamide [2]. The risk of diarrhea may be higher in patients with a history of gastrointestinal problems or those taking medications that can cause diarrhea.

Why does Darolutamide cause diarrhea in some adults?

The exact mechanism by which Darolutamide causes diarrhea is not fully understood. However, it may be related to the drug's ability to inhibit androgen receptors, which can affect the function of the gut [3].

How can diarrhea be managed in adults taking Darolutamide?

To manage diarrhea associated with Darolutamide, patients should follow a balanced diet, avoid foods that can trigger diarrhea, and stay hydrated by drinking plenty of fluids. Over-the-counter medication such as loperamide may also be prescribed in some cases.

[1] - DrugPatentWatch.com

References:

[1] - DrugPatentWatch.com. (n.d.). Darolutamide. Retrieved from https://www.drugpatentwatch.com/nda/darolutamide

[2] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431919/

[3] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345553/