Which medical conditions rule out cosentyx use?

What medical conditions contraindicate Cosentyx use?

Cosentyx (secukinumab) is a biologic medication used to treat various inflammatory conditions, including psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. While it can be an effective treatment, there are certain medical conditions that may contraindicate its use or require caution.

Malignancies and autoimmune disorders [1]

According to the Cosentyx prescribing information, individuals with a history of malignancies, including lymphoma, or autoimmune disorders such as rheumatoid arthritis, lupus, or vasculitis, may be contraindicated for Cosentyx use. This is because the underlying disease or treatment may increase the risk of adverse reactions to Cosentyx.

Live vaccines and vaccinations [2]

Individuals receiving live vaccines, such as the flu or MMR vaccine, are contraindicated for Cosentyx use, as Cosentyx can suppress the immune response. Additionally, patients receiving Cosentyx should not receive live vaccines for at least 2 months before, during, or 4 weeks after the treatment.

Infections [3]

Cosentyx may increase the risk of infections, particularly serious bacterial and opportunistic infections, in individuals with a history of recurrent infections, HIV infection, or those on immunosuppressive therapy. Patients with active infections, including tuberculosis, should not initiate Cosentyx treatment.

Severe liver disease [4]

Individuals with severe liver disease, such as cirrhosis, may require caution when initiating Cosentyx treatment. Liver enzymes should be monitored closely to assess for potential liver damage.

Breastfeeding and pregnancy [5]

It is not known whether Cosentyx is excreted in human milk, so caution is advised for breastfeeding mothers. Also, while Cosentyx has not been studied in pregnant women, animal studies suggest that it may harm a fetus. Pregnancy should be avoided while taking Cosentyx.

Other contraindications and precautions [6]

Other conditions that may require caution or contraindication for Cosentyx use include:

* Hypersensitivity reactions
* Neurological disorders
* History of depression or anxiety
* Alcohol use disorder
* Hypersensitivity to active or excipients of Cosentyx

Sources:

1. https://www.cosentyx.com/for-patients/what-is-cosentyx/indications
2. https://www.cosentyx.com/for-patients/what-is-cosentyx/precautions
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741155/
4. https://www.cosentyx.com/for-patients/what-is-cosentyx/dosage-and-administration
5. https://www.drugs.com/cdi/secukinumab.html
6. https://www.cosentyx.com/for-patients/what-is-cosentyx/indications

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