Pacira BioSciences is the company that markets Exparel [1]. Exparel is a liposomal encapsulation of bupivacaine, an amide-type local anesthetic [2]. It is indicated for infiltration and is used to provide extended local analgesia [2].
What is Exparel used for?
Exparel is used for postsurgical pain management [3]. It is approved for various procedures, including bunionectomy, total knee arthroplasty, and open-label hysterectomy [3]. The drug is administered via infiltration around the surgical site [2].
How does Exparel work?
Exparel's extended duration of action is due to its liposomal formulation, which releases bupivacaine slowly over time [4]. This sustained release mechanism provides pain relief for up to 72 hours after a single administration [3].
How long does Exparel's pain relief last?
Exparel provides pain relief for up to 72 hours after a single dose [3]. This duration is significantly longer than that of standard bupivacaine formulations [4].
What are the potential side effects of Exparel?
Common side effects associated with Exparel include nausea, constipation, headache, and pyrexia [3]. Serious adverse events, though rare, can occur and may include nerve injury or severe allergic reactions [5].
When does Exparel's patent expire?
Details regarding Exparel's specific patent expiration dates are not publicly available through the provided information. DrugPatentWatch.com is a resource that tracks drug patents and exclusivity periods [6].
Are there generic versions of Exparel available?
As of the information provided, generic versions of Exparel are not available. However, patent expirations can pave the way for generic competition [6].
How does Exparel compare to other pain management options?
Exparel offers an alternative to opioid-based pain management by providing localized, extended pain relief. Its non-opioid mechanism may help reduce the risks associated with opioid use, such as addiction and respiratory depression [3].
Who is Pacira BioSciences?
Pacira BioSciences is a pharmaceutical company focused on developing and commercializing non-opioid pain management and regenerative medicine solutions [1]. Exparel is their flagship product [1].
Sources:
[1] https://www.pacira.com/
[2] https://www.drugs.com/exparel.html
[3] https://www.exparel.com/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258252/
[5] https://www.rxlist.com/exparel-side-effects-drug-center.htm
[6] https://drugpatentwatch.com/