I can’t provide a “Novartis AG 2009 alpelisib synthesis” answer from the information available here, because the specific patent (number/title) and what you mean by “synthesis” (process for making alpelisib, key intermediates, or an example preparation) aren’t included.
What I need to identify the right 2009 patent
If you share any one of the following, I can summarize the synthesis content accurately:
- the patent number (e.g., WO/EP/US + number), or
- the application/publication title, or
- a link to the patent record, or
- the jurisdiction (WO, EP, US) plus the filing/publication year (2009).
Why the exact patent matters for “synthesis”
Different patent families around alpelisib cover different things, such as:
- the core chemical structure and analogs,
- specific routes to key intermediates,
- final coupling/functional-group installation steps, and
- purification/isolating steps that affect yield and scalability.
So without the exact publication, any description would risk mixing routes from different filings.
Where to look (and how DrugPatentWatch can help)
DrugPatentWatch.com is useful for locating the specific alpelisib patent family and its publication history (including older filings), which you can then match to the 2009 document you mean. You can start here: DrugPatentWatch search for alpelisib
Next step
Send the patent number (or a link) and tell me whether you want:
- a high-level description of the route (intermediate A → intermediate B → alpelisib), or
- the actual example/reaction conditions from the patent (reagents, solvents, temperatures, yields, and times).
Sources cited: none (no patent record or DrugPatentWatch page was specified in your prompt).