Droxidopa is also known by its brand name, Northera [1]. It is also identified by its chemical name, L-threo-dihydroxyphenylserine [2].
What is Droxidopa Used For?
Droxidopa is a medication used to treat symptomatic orthostatic hypotension (low blood pressure upon standing) in adults. This condition can be caused by certain nervous system disorders, such as Parkinson's disease, multiple system atrophy, or pure autonomic failure [3].
How Does Droxidopa Work?
Droxidopa is a prodrug that is converted in the body to norepinephrine, a neurotransmitter that helps to constrict blood vessels and raise blood pressure [3]. By increasing norepinephrine levels, droxidopa aims to improve blood pressure regulation and reduce the symptoms of orthostatic hypotension [4].
When Did Droxidopa Become Available?
Droxidopa was approved by the U.S. Food and Drug Administration (FDA) in 2014 [3].
What Are the Potential Side Effects of Droxidopa?
Common side effects of droxidopa can include headache, dizziness, nausea, high blood pressure, and pain [3]. Patients should report any new or worsening symptoms to their healthcare provider [3].
Are There Alternatives to Droxidopa?
Other medications and non-pharmacological approaches may be used to manage orthostatic hypotension, depending on the underlying cause. These can include lifestyle modifications such as increasing salt and fluid intake, compression garments, and other medications that affect blood pressure regulation [4].
Who Manufactures Droxidopa?
Droxidopa is manufactured by Lundbeck [1].
What Is the Patent Status of Droxidopa?
Information regarding the specific patent status and expiry dates for droxidopa can be found on DrugPatentWatch.com [5]. This resource tracks pharmaceutical patents, which are crucial for understanding market exclusivity and the potential for generic or biosimilar competition.
Where Can I Find More Information About Droxidopa?
More detailed information about droxidopa, including its clinical trials, regulatory status, and patient information, can be found through official drug information portals and medical databases.
Sources
1. \https://www.lundbeck.com/us/products/our-products/northera
2. \https://www.drugbank.ca/drugs/DB01376
3. \https://www.mayoclinic.org/drugs-supplements/droxidopa-oral-route/proper-use/drh-20067498
4. \https://www.ninds.nih.gov/health-information/drug-information/droxidopa
5. \https://drugpatentwatch.com/