Can Keytruda (pembrolizumab) cause nausea?
Yes. Nausea is listed as a possible side effect of Keytruda (pembrolizumab). [1]
How common is nausea with Keytruda?
How often nausea happens depends on the source and the type of reporting (clinical trials vs. post-marketing reports). In drug safety labeling, it appears among the side effects patients may experience. [1]
Could nausea be a sign of something more serious?
Sometimes nausea can be related to inflammation from immune therapy (immune-related adverse events) or other complications. Seek urgent medical care if nausea is accompanied by severe symptoms such as persistent vomiting, severe abdominal pain, dehydration, black/bloody stools, or signs of liver problems (yellowing of the skin/eyes). [1]
What should patients do if they feel nauseated after Keytruda?
Contact the prescribing clinician so they can assess severity and rule out immune-related side effects. Your care team may recommend anti-nausea medications, hydration strategies, and whether Keytruda dosing should be adjusted based on the underlying cause. [1]
Is nausea different from other common Keytruda stomach side effects?
Nausea can overlap with other gastrointestinal effects reported with Keytruda, such as diarrhea or abdominal discomfort. If symptoms are ongoing or worsening, it’s important to get medical guidance rather than treating at home alone. [1]
Sources:
[1] https://www.drugs.com/keytruda.html