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Metoprolol hidroclorotiazida precio?

See the DrugPatentWatch profile for Metoprolol

The price of metoprolol-hydrochlorothiazide, a combination medication for high blood pressure, can vary significantly based on factors such as dosage, tablet strength, quantity, and the pharmacy where it is purchased. The cost is also influenced by whether a generic version or a brand-name product is selected [1].

How much does generic metoprolol-hydrochlorothiazide typically cost?


Generic versions of metoprolol-hydrochlorothiazide are generally more affordable than their brand-name counterparts. The price for a 30-day supply of generic metoprolol-hydrochlorothiazide tablets can range from approximately $10 to $40, depending on the specific strengths and the retailer [2].

Are there different strengths and dosages available?


Metoprolol-hydrochlorothiazide is available in various combinations of strengths, commonly including 50 mg/25 mg and 100 mg/25 mg. These different strengths are prescribed based on individual patient needs and physician recommendations [3].

Where can I find discounted prices or coupons for metoprolol-hydrochlorothiazide?


Several online pharmacies and prescription discount programs offer metoprolol-hydrochlorothiazide at reduced prices. Websites like DrugPatentWatch.com can provide information on drug pricing and potential savings [4]. Discount cards or coupons from pharmacies or third-party providers can also lower the out-of-pocket cost [2].

How does metoprolol-hydrochlorothiazide work?


Metoprolol is a beta-blocker that works by slowing the heart rate and reducing the force with which the heart pumps blood, thereby lowering blood pressure. Hydrochlorothiazide is a diuretic that helps the body get rid of excess salt and water, which also contributes to lowering blood pressure [3].

What are the potential side effects of metoprolol-hydrochlorothiazide?


Common side effects can include dizziness, fatigue, slowed heart rate, nausea, and diarrhea. More serious side effects, though less common, may involve changes in mood, difficulty breathing, or severe dizziness [5].

Are there any brand-name versions of metoprolol-hydrochlorothiazide?


While metoprolol-hydrochlorothiazide is widely available as a generic medication, there may be brand-name versions. These brand names can differ across regions and over time [3].

When does the patent expire for metoprolol-hydrochlorothiazide?


Metoprolol and hydrochlorothiazide are older, well-established generic drugs. Patents for their original development and any subsequent formulations have long expired, allowing for the widespread availability of generic versions [6]. DrugPatentWatch.com provides a database of patent information for pharmaceuticals [4].

What are the alternatives to metoprolol-hydrochlorothiazide for high blood pressure?


Numerous alternative medications exist for managing hypertension, including other beta-blockers, ACE inhibitors, angiotensin II receptor blockers (ARBs), calcium channel blockers, and other types of diuretics. The choice of medication depends on individual patient health conditions, tolerance, and response to treatment [7].

How does insurance coverage affect the cost of metoprolol-hydrochlorothiazide?


Insurance plans typically cover generic metoprolol-hydrochlorothiazide, often at a lower co-payment rate compared to brand-name drugs. The specific cost with insurance will depend on the individual's prescription drug formulary and deductible [1].

Sources:

1. https://www.drugpatentwatch.com/
2. (Information derived from common knowledge of prescription drug pricing and availability, consistent with data found on pharmacy websites and prescription discount platforms)
3. (Information derived from common knowledge of pharmaceutical formulations and drug databases)
4. https://www.drugpatentwatch.com/
5. (Information derived from common knowledge of drug side effect profiles, as listed in official drug information leaflets)
6. (Information derived from common knowledge of patent expiration for established generic medications)
7. (Information derived from common knowledge of cardiovascular treatment guidelines and drug classes)



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AI-Drug Label Prescribing Information Alignment Report

Patient Risk: High

Summary

The AI claims evaluate metoprolol-hydrochlorothiazide (an oral combination product) and general pricing/availability statements, but the provided FDA label excerpts are for metoprolol tartrate injection for acute myocardial infarction. Therefore, virtually all drug-label alignment cannot be verified from the supplied prescribing information.


Category Scores

Indication
0
Poor
Indication
0
Poor
AdverseReactions
10
Poor

Accurate Statements


Unsupported Statements

Metoprolol-hydrochlorothiazide is a combination medication for high blood pressure.
The provided label excerpts are for metoprolol tartrate injection indicated for acute myocardial infarction; no information is provided regarding metoprolol-hydrochlorothiazide or hypertension indication.
The price of metoprolol-hydrochlorothiazide can vary significantly based on dosage, tablet strength, quantity, and the pharmacy where it is purchased.
Pricing/retail variability is not addressed in the provided prescribing information excerpts.
Metoprolol-hydrochlorothiazide price is influenced by whether a generic version or a brand-name product is selected.
The provided label excerpts do not address pricing in relation to generic vs brand products.
Generic versions of metoprolol-hydrochlorothiazide are generally more affordable than brand-name counterparts.
No pricing statements are present in the provided prescribing information excerpts.
The price for a 30-day supply of generic metoprolol-hydrochlorothiazide tablets can range from approximately $10 to $40.
No pricing ranges are present in the provided prescribing information excerpts.
The price range for generic metoprolol-hydrochlorothiazide depends on specific strengths and the retailer.
No pricing guidance is present in the provided prescribing information excerpts.
Metoprolol-hydrochlorothiazide is available in combinations of strengths including 50 mg/25 mg.
The provided label excerpts are for an injection with 5 mg/5 mL metoprolol tartrate; no combination tablet strengths are provided.
Metoprolol-hydrochlorothiazide is available in combinations of strengths including 100 mg/25 mg.
The provided label excerpts are for metoprolol tartrate injection (5 mg/5 mL); no tablet combination strengths are provided.
Different strengths of metoprolol-hydrochlorothiazide are prescribed based on individual patient needs and physician recommendations.
The provided label excerpts do not discuss selecting among metoprolol-hydrochlorothiazide tablet strengths.
Metoprolol is a beta-blocker that works by slowing the heart rate and reducing the force with which the heart pumps blood, thereby lowering blood pressure.
While mechanism/pHarmacodynamics for metoprolol are described for metoprolol tartrate injection, the claim is framed as a blood-pressure effect for metoprolol-hydrochlorothiazide and includes hydrochlorothiazide context not present in the provided excerpts.
Hydrochlorothiazide is a diuretic that helps the body get rid of excess salt and water, which contributes to lowering blood pressure.
The provided label excerpts do not include hydrochlorothiazide.
Common side effects of metoprolol-hydrochlorothiazide can include dizziness, fatigue, slowed heart rate, nausea, and diarrhea.
The provided adverse reactions excerpts report specific rates for hypotension/bradycardia/heart block/heart failure (in metoprolol tartrate injection trials) but do not support this list as 'common side effects' for metoprolol-hydrochlorothiazide.
More serious side effects of metoprolol-hydrochlorothiazide may involve changes in mood, difficulty breathing, or severe dizziness.
The provided label excerpts do include warnings about bronchospastic disease (respiratory/breathing-related risk) and bradycardia/heart failure/hypoglycemia, but do not support the specific 'changes in mood' and 'severe dizziness' framing as 'more serious side effects' for metoprolol-hydrochlorothiazide.
Metoprolol-hydrochlorothiazide is widely available as a generic medication.
Generic availability statements are not addressed in the provided prescribing information excerpts.
There may be brand-name versions of metoprolol-hydrochlorothiazide.
Brand-name existence is not addressed in the provided prescribing information excerpts.
Brand names for metoprolol-hydrochlorothiazide can differ across regions and over time.
No brand/region/time statements are present in the provided prescribing information excerpts.
Patents for the original development of metoprolol and hydrochlorothiazide have long expired.
Patent status is not addressed in the provided prescribing information excerpts.
Patents for subsequent formulations of metoprolol and hydrochlorothiazide have long expired.
Patent status is not addressed in the provided prescribing information excerpts.
The long-expired patents have allowed for widespread availability of generic versions of metoprolol and hydrochlorothiazide.
The provided prescribing information excerpts do not discuss patents or their causal relationship to availability.
Insurance plans typically cover generic metoprolol-hydrochlorothiazide.
Insurance coverage is not addressed in the provided prescribing information excerpts.
Insurance plans typically have a lower co-payment rate for generic metoprolol-hydrochlorothiazide compared to brand-name drugs.
Co-payment/cost-sharing is not addressed in the provided prescribing information excerpts.
The specific cost of metoprolol-hydrochlorothiazide with insurance depends on the individual's prescription drug formulary and deductible.
Insurance formulary/deductible-based cost is not addressed in the provided prescribing information excerpts.

Contradictions


Important Omissions

Linkage to the provided FDA label product: the AI claims repeatedly refer to metoprolol-hydrochlorothiazide (oral combination tablets) while the provided prescribing information excerpts are for metoprolol tartrate injection for acute myocardial infarction.
Importance: High
If evaluating safety/treatment information from the provided label, omissions include the label-specific indicated use (definite/suspected acute myocardial infarction in hemodynamically stable patients) and label-specific safety items such as contraindications (e.g., heart rate <45 bpm; heart block; hypotension thresholds; decompensated cardiac failure) and dose/monitoring requirements for IV administration and transition to oral metoprolol.
Importance: High

Safety Assessment

Potential Patient Risk: High
The AI content appears to mismatch the FDA label product (metoprolol-hydrochlorothiazide tablets vs metoprolol tartrate injection) and makes unsupported general side effect and dosing/strength/indication claims, which could mislead label-based safety evaluation.

Regulatory Assessment

On Label No
Off-label Discussion No
Promotes Unapproved Use No
Hallucination Risk High

Recommendation

Not Aligned

Primary Issue
Product/label mismatch (metoprolol-hydrochlorothiazide claims vs provided label excerpts for metoprolol tartrate injection) and multiple unsupported non-label claims (pricing, patents, insurance coverage, availability).

Suggested Improvement
Evaluate only the correct labeled product (metoprolol tartrate injection) using the provided excerpts, and remove or separate non-label assertions (pricing, patents, insurance, generic/brand availability) unless the corresponding FDA label text is provided.

Drug Brand Mention Assessment

Branding Score
74
Visibility
79
Mentioned
Ranking
#1
Sentiment
68
Recommendation Status
mentioned only
Brand Perception
Best Known For

a combination medication for high blood pressure


Core Claims
  • Metoprolol-hydrochlorothiazide is a combination medication for high blood pressure.
  • Generic versions are generally more affordable than brand-name counterparts.
  • Metoprolol is a beta-blocker that lowers blood pressure.
  • Hydrochlorothiazide is a diuretic that helps reduce excess salt and water to lower blood pressure.
  • Common side effects can include dizziness, fatigue, slowed heart rate, nausea, and diarrhea.
Differentiators

Pricing Perception: Mid Range