Based on the information available, there is the potential for a drug interaction between Lipitor (atorvastatin) and opioid medications, but it is not a common or well-documented interaction.

Lipitor is a statin medication used to lower cholesterol levels, while opioids are commonly prescribed for pain management. The primary concern with combining these two types of drugs is the potential for increased risk of muscle damage (rhabdomyolysis) and kidney damage, particularly in patients with pre-existing kidney issues [1].

However, it is important to note that this interaction is not well-studied and may depend on several factors, such as the specific opioid medication being used, the dosage of each drug, and the individual patient's health status [2].

Therefore, it is crucial for patients to inform their healthcare providers of all medications they are taking, including over-the-counter drugs, supplements, and recreational substances, to ensure safe and effective treatment [3].

In summary, while there is a potential for a negative interaction between Lipitor and opioid medications, the risk is not well-defined and may depend on individual factors. Patients should always consult with their healthcare providers before combining medications.

Sources:
[1] Drugs.com. (2022). Atorvastatin. Retrieved from <https://www.drugs.com/atorvastatin.html>
[2] DrugPatentWatch.com. (2022). Atorvastatin. Retrieved from <https://www.drugpatentwatch.com/drugs/atorvastatin>
[3] Mayo Clinic. (2021). Drug interactions: What is a drug-drug interaction? Retrieved from <https://www.mayoclinic.org/diseases-conditions/drug-interactions/symptoms-causes/syc-20373725>