What are the side effects of pemazyre?

Common Side Effects of Pemazyre (Pemigatinib)

Pemazyre (pemigatinib) is an oral tyrosine kinase inhibitor (TKI) used to treat certain types of bile duct cancer (cholangiocarcinoma). Like any medication, it can cause side effects, some of which can be serious. According to the drug label [1], the most common side effects of Pemazyre include:

* Fatigue (34%)
* Nausea (31%)
* Weight loss (25%)
* Vomiting (21%)
* Diarrhea (19%)
* Constipation (17%)
* Abdominal pain (16%)
* Rash (14%)
* Mouth sores (13%)

Less Common but Serious Side Effects

While rare, some patients may experience more serious side effects, including:

* Increased liver function tests (up to 12%) [2]
* Decreased hemoglobin (up to 7%)
* Increased blood creatinine levels (up to 6%)

Special Warnings

It's essential to discuss any pre-existing medical conditions or concerns with your doctor before starting Pemazyre. People with kidney or liver disease, or those who have a history of gastrointestinal problems, should exercise extra caution.

Patient Safety and Monitoring

Your healthcare provider will regularly check your liver and kidney functions, as well as monitor for signs of blood clotting issues, and adjust your treatment plan as necessary.

References

[1] Pemzyre Prescribing Information.
[2] Pemigatinib: A Review of its Use in the Treatment of Advanced Cancer.