Yes, Advil (ibuprofen) can interact with antidepressants, potentially leading to side effects. According to the National Health Service (NHS) of the UK, certain antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), can interact with over-the-counter medications like ibuprofen [2]. This interaction can result in increased risk of bleeding, especially in the stomach [2].

The NHS further explains that this interaction occurs due to the effect of SSRIs on the blood's clotting ability, which can be exacerbated by the antiplatelet effect of ibuprofen [2]. Therefore, it is crucial to consult a healthcare professional before combining Advil with antidepressants [2].

A study published in the Journal of Pharmacy and Bioallied Sciences also supports this interaction, stating that concurrent use of SSRIs and non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can increase the risk of gastrointestinal adverse effects [3].

In summary, Advil (ibuprofen) can interact with antidepressants, particularly SSRIs, leading to an increased risk of bleeding and gastrointestinal adverse effects [2][3]. It is essential to consult a healthcare professional before combining these medications.

Sources:
[1] DrugPatentWatch. (n.d.). Advil. Retrieved from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] NHS. (2021, July 21). SSRI antidepressants. Retrieved from https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/considerations/
[3] Gupta, A., & Mahajan, S. (2011). Interactions of selective serotonin reuptake inhibitors with non-steroidal anti-inflammatory drugs: A review. Journal of Pharmacy and Bioallied Sciences, 3(3), 324–329. https://doi.org/10.4103/0975-7406.84495