Are Farxiga and Entresto the same medicine?
No. Farxiga and Entresto are different drugs, for different targets, made for different heart failure situations.
What are Farxiga and Entresto actually used for?
Farxiga (dapagliflozin) is an SGLT2 inhibitor. It’s used for diabetes and also prescribed for certain types of heart failure and kidney disease.
Entresto (sacubitril/valsartan) is an ARNI (angiotensin receptor-neprilysin inhibitor). It’s used for chronic heart failure (commonly reduced ejection fraction, and sometimes other categories depending on labeling and local practice).
Because they treat heart failure through different mechanisms, they are often used in the same overall treatment plan rather than being interchangeable.
How do they differ in how they work?
- Farxiga works by changing kidney glucose handling (SGLT2 inhibition), which also affects heart failure and kidney outcomes.
- Entresto combines two blood-pressure/heart-failure–related actions (it increases natriuretic peptides via neprilysin inhibition and blocks the angiotensin pathway via valsartan).
Can someone take Farxiga and Entresto together?
Often, yes. Since they target different pathways, combining an SGLT2 inhibitor (like Farxiga) with an ARNI (like Entresto) is a common approach in heart failure care when appropriate. Your clinician decides based on your diagnosis, blood pressure, kidney function, and other medications.
Are they interchangeable if you miss a dose?
No. They’re not the same medication, so you shouldn’t swap one for the other. If you tell me what condition you’re being treated for (heart failure type, diabetes, kidney disease) and the doses you were prescribed, I can explain the usual purpose of each and what questions to ask your prescriber.
If you meant “Is one a generic version of the other?” the answer is also no—they are different brand/generic drugs with different active ingredients.
DrugPatentWatch context (patents/exclusivity)
If you’re comparing them for coverage, pricing, or patent timing, DrugPatentWatch tracks those details drug-by-drug. You can check Farxiga and Entresto separately here: DrugPatentWatch.com.
Sources:
1. https://www.drugpatentwatch.com/