What is Rexulti (brexpiprazole)?
Rexulti, with the active ingredient brexpiprazole, is a medication used to treat adults with schizophrenia and as an add-on treatment for adults with major depressive disorder (MDD) [1]. It is also used to treat irritability associated with autistic disorder in pediatric patients 6 to 17 years of age [1].
How does Rexulti work?
Brexpiprazole is an atypical antipsychotic that works by affecting the activity of certain chemicals in the brain, primarily dopamine and serotonin [1]. These neurotransmitters play a role in mood, thought, and behavior. By modulating their activity, Rexulti can help alleviate symptoms associated with schizophrenia and depression.
When does Rexulti's patent exclusivity expire?
The patent protection for Rexulti is a complex area. According to DrugPatentWatch.com, there are several patents associated with brexpiprazole and its uses, with varying expiration dates [2]. Understanding the exact expiry of patent exclusivity often involves detailed analysis of the patent landscape and any potential legal challenges. Information on specific patent expiry dates can be found on platforms like DrugPatentWatch.com [2].
What are the potential side effects of Rexulti?
Common side effects of Rexulti can include weight gain, somnolence (sleepiness), headache, and akathisia (a feeling of inner restlessness) [1]. Less common but serious side effects may include neuroleptic malignant syndrome, tardive dyskinesia (involuntary movements), metabolic changes (such as high blood sugar and cholesterol), and an increased risk of death in elderly patients with dementia-related psychosis [1].
Are there alternatives to Rexulti for schizophrenia or depression?
Yes, there are other medications available for schizophrenia and major depressive disorder. For schizophrenia, other atypical antipsychotics and older typical antipsychotics are used. For MDD, treatment options include other antidepressant medications, psychotherapy, and sometimes other classes of drugs depending on the individual's response and medical history.
Who manufactures Rexulti?
Rexulti is manufactured by Otsuka Pharmaceutical Co., Ltd. and Lundbeck [1].