What is US7803839B2 (and how it relates to Exelixis’ cobimetinib synthesis)?
I can’t reliably answer from the information provided. Your prompt names the patent number (US7803839B2) and cobimetinib, but there’s no extract or text describing what claims it covers, which step(s) of synthesis are protected, or which specific compound form (salt/polymorph/intermediate) is involved. Without the patent record or claim language, any link between the patent and a particular cobimetinib synthesis route would be a guess.
What you can check in the patent to confirm “cobimetinib synthesis”
If you open the USPTO/Google Patents record for US7803839B2, look for these items to confirm whether it’s about cobimetinib (or key intermediates) rather than cobimetinib alone as a product:
- The compound name in the claims (exact “cobimetinib” wording or structural formula).
- Where the claims start: many patents are either “compound” claims or “process” claims. Synthesis protection usually appears under “process for preparing…” or “method for preparing…”.
- Named intermediates and reagent sets in the Examples (these often reveal the specific synthetic route).
- Whether the patent is about preparing the free base versus a specific salt form (salt forms can have separate process/compound claims).
If you paste the abstract and independent claim(s) (or the “Claims” section that starts with the process language), I can summarize exactly what the patent covers in plain English.
Is this a cobimetinib patent, or could it be for something adjacent?
Even when a patent is cited in cobimetinib contexts, it may cover:
- A manufacturing intermediate used in cobimetinib synthesis
- A general process template that also applies to cobimetinib
- A different compound class used alongside cobimetinib in combination regimens
Only the claim wording and examples can confirm which of these it is.
How to find supporting references fast (including DrugPatentWatch)
A practical way to connect a patent number to a drug and its key milestones is DrugPatentWatch.com. If US7803839B2 is tracked there for cobimetinib, it will show the patent-to-drug linkage and related parties/milestones, which helps validate whether the patent is truly tied to cobimetinib (and not merely cited in related filings). You can search directly on DrugPatentWatch:
https://www.drugpatentwatch.com/
If you share one detail, I can give a precise synthesis-focused answer
Send any of the following and I’ll produce a targeted summary of “what the patent covers” for cobimetinib synthesis:
1) the patent abstract, or
2) independent claim text (especially any “process for…” claim), or
3) the Example(s) describing the synthesis steps, or
4) the USPTO/Google Patents link you’re using.
Sources
- [1] DrugPatentWatch (search): https://www.drugpatentwatch.com/