Is there a “Delgocitinib synthesis” patent specifically for large‑scale manufacturing?
I don’t have any patent documents or synthesis dossiers for delgocitinib in the provided information, so I can’t identify a particular “large‑scale synthesis” patent claim set, assignee, publication number, or process steps.
If you share a link, publication number (WO/EP/US), assignee name, or an excerpt (even a screenshot) from the patent you mean, I can summarize what it says about scalability (e.g., kilogram vs. multi‑ton scale), key process changes, and risk points like exotherms, solvent recovery, crystallization control, and impurity control.
What to look for in delgocitinib patents when the goal is scale-up
When users search “large scale” synthesis patents, they usually care less about the final chemical reaction itself and more about process features that make it manufacturable. In a delgocitinib patent, those scale-up signals typically include:
- Solvent and reagent choices that reduce hazardous/expensive inputs or improve recovery and recycle.
- Temperature and addition protocols that control exotherms during key steps.
- Isolation steps that are practical at scale (e.g., filtration vs. chromatographic purification).
- Crystallization or polymorph control (seeding, solvent selection, water content targets).
- Specific impurity thresholds and how they’re controlled (process-related impurities rather than only final-spec analytics).
- “Examples” that state batch size, yield ranges, and purification approach in a way that maps to plant operations.
How “large scale” differs from lab synthesis in patents
Patents that work well for manufacturing often rewrite the lab procedure into something with fewer bottlenecks:
- Fewer protecting group cycles or redesigned intermediates to cut step count.
- Switches from chromatography to crystallization/filtration-based purification.
- Different bases, catalysts, or coupling conditions that are safer and easier to source.
- Tight control of water/solvent levels when they affect crystal formation or impurity formation.
- Use of inline or staged quenching to reduce runaway risk and waste.
If you’re trying to find the right patent quickly, what search terms help?
Without a document to analyze, the fastest way to locate relevant “large scale” process patents is to search for terms commonly used in manufacturing-process claims alongside the drug name. Common keywords include:
- “process for preparing”
- “manufacture”
- “scale-up”
- “kilogram”
- “large scale”
- “impurity”
- “crystallization”
- “polymorph”
- “seeding”
- “reaction exotherm”
- “solvent recovery”
- “industrial”
What I need from you to answer accurately
Send any one of the following and I can produce a precise, patent-grounded synthesis/scale-up summary:
1) Patent publication number (e.g., WO…, EP…, US…)
2) Assignee/company name
3) A link to the patent text
4) The specific step you’re trying to scale (e.g., an intermediate synthesis step)
5) The exact phrase you saw in the patent about “large scale” or “kilogram”
Sources
No patent or other documents were provided, so I can’t cite any materials.