Corlanor is a brand name for the medication ivabradine, which is used to treat certain types of heart failure [1]. It is prescribed for patients with symptomatic stable chronic heart failure with a reduced ejection fraction, who are in normal sinus rhythm with a resting heart rate of 70 beats per minute or more, and who are on an maximally tolerated dose of beta-blockers, or who have a contraindication to beta-blocker use [1][2].
How does Corlanor work?
Corlanor functions by selectively inhibiting the If current in the sinoatrial node, which is the heart's natural pacemaker [1][3]. This action slows the heart rate without affecting other cardiac parameters such as blood pressure or myocardial contractility [1][3]. By reducing the heart rate, Corlanor helps to decrease the heart's workload and oxygen demand [1][2].
What are the uses of ivabradine?
Ivabradine is indicated for the treatment of symptomatic stable chronic heart failure in adult patients who are in normal sinus rhythm with a resting heart rate of 70 beats per minute or more. It is used in conjunction with or as an alternative to beta-blockers, particularly in patients who cannot tolerate beta-blockers or have residual symptoms despite being on a maximally tolerated dose of these medications [1][2].
When might Corlanor not be suitable for a patient?
Corlanor is not intended for patients with sick sinus syndrome, sinoatrial (SA) block, or third-degree atrioventricular (AV) block, as these conditions can be exacerbated by a further reduction in heart rate [1]. It is also contraindicated in patients with a resting heart rate of less than 60 beats per minute before treatment, severe hepatic impairment, and those taking strong CYP3A4 inhibitors like ketoconazole or ritonavir [1][4]. Additionally, it should not be used in patients with acute myocardial infarction or severe hypotension [1].
What are the potential side effects of Corlanor?
Common side effects associated with Corlanor include bradycardia (slow heart rate), visual disturbances such as phosphenes (flashes of light), and hypertension [1][2]. Other reported side effects may include irregular heart rhythms, dizziness, and headache [1]. Patients are advised to report any new or worsening symptoms to their healthcare provider [1].
When does ivabradine's patent expire?
Information regarding the patent expiry for ivabradine, including the Corlanor brand, can be found on specialized pharmaceutical patent databases [5]. These databases track patent protection periods, which can vary by region and may include extensions.
Are there other medications like Corlanor?
While Corlanor is a selective If current inhibitor, other medications are used to manage heart failure. These include beta-blockers, ACE inhibitors, ARBs, ARNIs, and mineralocorticoid receptor antagonists [2]. The choice of medication depends on the patient's specific condition, symptoms, and tolerance to different drug classes.