What is Avanafil (Stendra)?
Avanafil, marketed as Stendra, is a prescription medication used to treat erectile dysfunction (ED) [1]. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors [1].
How does Avanafil work?
Avanafil works by increasing blood flow to the penis during sexual stimulation [1]. It achieves this by inhibiting the PDE5 enzyme, which normally breaks down cyclic guanosine monophosphate (cGMP). cGMP causes smooth muscle relaxation, allowing blood to enter the penis and result in an erection [1].
What are the benefits of Stendra compared to other ED medications?
Stendra is known for its rapid onset of action, with some individuals experiencing effectiveness as quickly as 15 minutes after taking the medication [2]. It also has a relatively long duration of action, potentially lasting up to 6 hours [2].
When does Stendra's patent expire?
Patent information for Stendra can be complex and may involve multiple patents covering the drug substance, manufacturing processes, and methods of use. DrugPatentWatch.com tracks patent expiry dates and can provide detailed information on specific patents related to Stendra [3]. As of late 2023, primary patents for avanafil have begun to expire, opening the door for generic competition [3].
Can generic versions of Stendra be available?
With the expiry of key patents, generic versions of avanafil are expected to become available. The availability of generics can lead to lower prices for consumers and increased market competition [3].
What are the risks and side effects of Stendra?
Common side effects of Stendra include headache, flushing, nasal congestion, and back pain [1]. More serious side effects can occur, particularly if taken with certain other medications. It is crucial for patients to discuss their full medical history and all medications they are taking with their doctor before starting Stendra [1].
Who should not take Stendra?
Stendra should not be taken by individuals using nitrate medications, which are often prescribed for chest pain (angina), as the combination can cause a dangerous drop in blood pressure [1]. It is also contraindicated for those with severe heart or liver problems, or who have had a recent stroke or heart attack [1].
How does Stendra compare to Viagra and Cialis?
Stendra, Viagra (sildenafil), and Cialis (tadalafil) are all PDE5 inhibitors used to treat ED. While they share a similar mechanism of action, differences exist in their onset of action, duration of effect, and potential side effect profiles [4]. Stendra is generally considered to act faster than Viagra and has a comparable duration to Viagra, while Cialis is known for its longer duration of action [2][4]. The choice among these medications often depends on individual patient needs, medical history, and physician recommendations [4].