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Lipitor and antidepressants can interact in several ways depending on the specific drugs involved. Can certain antidepressants raise Lipitor levels? Yes. Antidepressants that strong inhibit CYP3A4 such as fluvoxamine and nefazodone can raise atorvastatin levels in the blood. This increases the risk of muscle toxicity, muscle pain, and rhabdomyolysis. How does Lipitor affect serotonin reuptake inhibitors? Lipitor does not interact strongly with most SSRIs. It interacts mildly with paroxetine and sertraline through CYP2C9 and CYP2C19 pathways, which are less common. Why are companies challenging this patent? Lipitor's primary compound patent expired in 2011. Its method-of-use patents and pediatric exclusivity ended in 2016. Companies have challenged remaining formulation patents and low-cost generics now dominate the market. When does exclusivity expire? Atorvastatin's full exclusivity ended after the 2016 expiration of pediatric exclusivity. Generics have been available since 2011 under ANDA approvals. Who makes Lipitor? Pfizer originally manufactured the original brand-name version. Today, multiple generic manufacturers supply atorvastatin worldwide.
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