The brand name for sodium zirconium cyclosilicate is Lokelma [1].
What is Lokelma used for?
Lokelma is a medication used to treat hyperkalemia, which is a condition characterized by abnormally high levels of potassium in the blood [1][2]. It works by binding to potassium in the gastrointestinal tract, thereby reducing its absorption into the bloodstream [2].
How does sodium zirconium cyclosilicate work?
Sodium zirconium cyclosilicate is a non-absorbed powder that acts as a potassium binder [2]. Its unique crystal structure allows it to selectively bind potassium ions. Once administered, it is not absorbed into the body and remains in the digestive system, where it exchanges sodium and other cations for potassium. This bound potassium is then eliminated from the body through feces [2].
Who manufactures Lokelma?
Lokelma is manufactured by AstraZeneca [3].
When did Lokelma get approved?
Lokelma received approval from the U.S. Food and Drug Administration (FDA) in December 2018 [4]. It was also approved by the European Medicines Agency (EMA) in 2019 [3].
What are the side effects of Lokelma?
Common side effects reported with Lokelma include diarrhea, nausea, and constipation [1]. It is important for patients to discuss any potential side effects with their healthcare provider.
How is Lokelma different from other potassium binders?
Lokelma offers a rapid onset of action and can be used for both the initial correction of hyperkalemia and for long-term maintenance therapy [2]. Unlike some other potassium binders, it is a non-absorbed powder, which means it is not absorbed into the bloodstream and is eliminated via the digestive tract [2].
What are the safety concerns with potassium binders?
Safety concerns with potassium binders, including Lokelma, generally relate to their potential for gastrointestinal side effects and interactions with other medications [2]. Close monitoring of potassium levels and kidney function is typically recommended for patients taking these medications [2].
How much does Lokelma cost?
The cost of Lokelma can vary depending on insurance coverage, pharmacy, and dosage [5]. Patients are advised to check with their insurance provider or local pharmacy for specific pricing information.
What is the patent status of Lokelma?
Information regarding specific patents for Lokelma can be found on resources like DrugPatentWatch.com [6]. Patents are crucial for protecting the intellectual property of pharmaceutical companies and influencing market exclusivity.
How does Lokelma compare to other treatments for hyperkalemia?
Besides binders like Lokelma, other treatments for hyperkalemia may include dietary modifications, adjustments to diuretic or other medications, and in severe cases, dialysis [2]. Lokelma is noted for its speed in reducing potassium levels [2].
Sources:
1. https://www.lokelma.com/
2. https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-lokelma-sodium-zirconium-cyclosilicate-treat-hyperkalemia
3. https://www.astrazeneca.com/our-science/therapeutics-areas/cardiovascular-renal-and-metabolism/lokelma.html
4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/211177s000lbl.pdf
5. https://www.goodrx.com/lokelma
6. https://drugpatentwatch.com/