How often does ozempic use lead to pancreatitis?

How often does Ozempic use lead to pancreatitis?

Pancreatitis occurs in clinical trials of semaglutide at rates below 1 percent. Rates appear higher in real-world use, especially among patients with a history of pancreatitis.

How rare is pancreatitis with semaglutide?
Semaglutide-related pancreatitis is uncommon but documented. In the SUSTAIN trials, acute pancreatitis developed in 0.1 percent of semaglutide-treated patients compared with 0.2 percent in the placebo group. In the PIONEER oral semaglutide trials, the rate reached 0.1 percent. In the STEP trials for weight loss, 0.1 percent of patients on semaglutide 2.4 mg developed pancreatitis. [1]

What patient factors raise risk?
Patients who already have a history of pancreatitis or who have gallbladder disease show higher rates. Data from the FDA Adverse Event Reporting System show 190 cases of acute pancreatitis associated with semaglutide between 2017 and 2022. The agency has placed a warning on the Ozempic label advising caution in patients with prior pancreatitis.

What happens when patients develop pancreatitis?
Patients report sudden abdominal pain, nausea, and elevation in lipase and аmylase. The majority recover after discontinuation of the drug and supportive care. A few cases require hospitalization.