See the DrugPatentWatch profile for rybelsus
What side effects can Rybelus (semaglutide) cause?
Rybelsus (oral semaglutide) commonly causes gastrointestinal side effects, especially when starting treatment or increasing the dose. These effects can include nausea, vomiting, diarrhea, constipation, stomach (abdominal) pain, and indigestion. [1]
What are the more serious (less common) side effects to watch for?
More serious risks with semaglutide include dehydration from persistent vomiting or diarrhea, which can lead to kidney problems. There is also a risk of inflammation of the pancreas (pancreatitis), severe allergic reactions, and gallbladder problems (such as gallstones or cholecystitis). [1]
Can Rybelus cause low blood sugar?
Rybelsus by itself usually does not cause hypoglycemia (low blood sugar). However, the risk goes up when it is used with other diabetes medicines that can lower blood sugar, such as insulin or sulfonylureas (for example, glimepiride or glipizide). [1]
What symptoms mean you should contact a clinician urgently?
Seek urgent medical help if you have signs of pancreatitis (severe and persistent upper abdominal pain, sometimes with vomiting), symptoms of a serious allergic reaction (trouble breathing, facial or throat swelling, widespread rash), or signs of significant dehydration (dizziness, very low urine output). [1]
Does the side-effect profile change over time?
Gastrointestinal side effects are most common early in treatment and around dose increases. Many people find these symptoms lessen as the body adjusts and as dosing is gradually escalated. [1]
Patient questions: will nausea improve if I take it correctly?
Rybelsus has specific instructions for how to take it (timing relative to food and the way you swallow the tablet). Taking it as directed can help some people tolerate it better, though it does not eliminate side effects for everyone. [1]
Sources
[1] https://www.rybelsus.com/side-effects