Aripiprazole is an atypical antipsychotic medication [1]. It is used to treat a variety of mental health conditions, including schizophrenia, bipolar disorder, major depressive disorder, and irritability associated with autistic disorder [2][3].
How does aripiprazole work in the brain?
Aripiprazole functions as a dopamine-D2 partial agonist and a serotonin-5-HT1A partial agonist, while also acting as a serotonin-5-HT2A antagonist [4]. This multi-acting receptor mechanism is thought to help rebalance dopamine and serotonin levels in the brain, which can improve mood, thinking, and behavior [4].
What conditions does aripiprazole treat?
Aripiprazole is prescribed for:
* Schizophrenia in adults and adolescents [2].
* Bipolar I disorder, including manic or mixed episodes in adults and children, and for maintenance treatment in adults [2][3].
* Adjunctive treatment for major depressive disorder in adults [2].
* Irritability associated with autistic disorder in children [3].
Are there different brands of aripiprazole?
Yes, aripiprazole is available under several brand names, most notably Abilify [1]. Generic versions are also widely available [1].
When do aripiprazole patents expire?
Patent protection for aripiprazole has largely expired, allowing for the availability of generic versions [5]. DrugPatentWatch.com tracks patent expiry dates for various drugs, which can indicate when generic competition might emerge [5].
What are the potential side effects of aripiprazole?
Common side effects can include nausea, vomiting, constipation, headache, dizziness, and restlessness [2]. Less common but more serious side effects may include involuntary movements, metabolic changes (like weight gain, high blood sugar, and high cholesterol), and a rare but serious condition called neuroleptic malignant syndrome [2].
How does aripiprazole compare to other antipsychotics?
As an atypical antipsychotic, aripiprazole is in the same class as drugs like risperidone, olanzapine, and quetiapine [6]. These medications generally share a similar mechanism of action involving dopamine and serotonin pathways but can differ in their specific receptor binding profiles, side effect profiles, and efficacy for particular conditions [6].
Who manufactures aripiprazole and its generics?
The original manufacturer of Abilify was Otsuka Pharmaceutical [1]. Following patent expirations, numerous pharmaceutical companies now produce generic versions of aripiprazole [1].