How to take Xofluza for flu treatment
Take Xofluza (baloxavir marboxil) as a single oral dose, with or without food, within 48 hours of flu symptom onset. For patients 5 years and older weighing at least 20 kg (44 lbs), it's one 40 mg tablet. Those weighing 80 kg (176 lbs) or more take one 80 mg tablet. Swallow the tablet whole; do not chew, crush, or split it.[1][2]
Dosage for children under 20 kg
Kids 5 years and older weighing less than 20 kg receive a single 2 mg/kg oral suspension dose, using the provided syringe. Shake the bottle well for 30 seconds before measuring.[1][2]
What if I miss the 48-hour window or have questions on timing
Xofluza works best started early, but doctors may still prescribe it later based on severity. It's approved for acute uncomplicated influenza in patients at high risk of complications.[1]
Common mistakes patients make and how to avoid them
Avoid antacids, dairy, or calcium-fortified drinks within 4 hours before or after the dose, as they reduce absorption. Store tablets and suspension at room temperature, away from moisture.[1][2]
Side effects to watch for
Most common are diarrhea, bronchitis, nausea, sinusitis, and headache. Seek medical help for allergic reactions like rash, swelling, or trouble breathing.[1]
Who shouldn't take Xofluza
Not for patients under 5 years, those with severe kidney disease, or complicated flu needing IV antivirals. It's not a flu vaccine substitute.[1][2]
Sources
[1]: Xofluza Prescribing Information (Genentech)
[2]: FDA Label for Xofluza