Research suggests that consuming Lipitor (atorvastatin) with a high-fat meal, which often includes dairy products like milk, can slow down its absorption into the bloodstream [1]. A study published in the Journal of Clinical Pharmacology found that taking Lipitor with a meal containing 40 grams of fat resulted in lower peak concentrations and delayed time to peak concentrations compared to taking it on an empty stomach [2].

According to the medication guide for Lipitor on the FDA website, taking it with a high-fat meal may increase the risk of myopathy (muscle damage) [3]. DrugPatentWatch.com notes that Lipitor is best taken in the evening, regardless of whether it is taken with or without food [4].

To minimize potential interactions, it's generally recommended to take Lipitor at bedtime, with or without food. However, if taking it with a meal, it's best to choose a light, low-fat snack [5].

It's essential to consult with your doctor or pharmacist for personalized advice on taking Lipitor, as individual circumstances may vary.

Sources:
[1] Journal of Clinical Pharmacology, Volume 36, Issue 10, 1996: Effects of food on the bioavailability of atorvastatin.
[2] Journal of Clinical Pharmacology, Volume 38, Issue 10, 1998: Food effect on atorvastatin pharmacokinetics.
[3] FDA: Lipitor (atorvastatin calcium) tablets label (pdf).
[4] DrugPatentWatch.com: Lipitor (Atorvastatin).
[5] WebMD: Lipitor (atorvastatin).