How do i use the rebif rebidose device?

How to Use the Rebif RebiDose Device

Rebif RebiDose is a prefilled autoinjector for subcutaneous Rebif (interferon beta-1a) injections, used to treat relapsing multiple sclerosis. It delivers 22 mcg or 44 mcg doses three times weekly. Always follow your doctor's instructions and the official prescribing information.[1]

Step-by-Step Injection Guide

1. Wash hands and clean the injection site (abdomen, back of upper arms, buttocks, or thighs) with alcohol. Rotate sites to avoid irritation.
   
2. Remove the device from refrigeration 30 minutes before use to reach room temperature. Do not shake.
   
3. Peel off the cap. Inspect the liquid—it should be clear and colorless. Discard if cloudy or discolored.
   
4. Hold the device upright (gray tip up). Press the gray tip firmly against skin at a 90-degree angle until it clicks (needle inserts).
   
5. Count to 10 slowly while pressing steadily—the yellow plunger moves to indicate delivery.
   
6. Release pressure; the needle retracts automatically. Dispose of the used device in a sharps container.
   
   Each device is single-use only.[1][2]
   
   

Where to Inject and Site Rotation

Inject into fatty areas: outer upper arms, abdomen (at least 2 inches from navel), upper buttocks, or front thighs. Avoid scarred, bruised, or irritated skin. Change sites by at least 1 inch each time to reduce injection-site reactions like redness or pain.[1]

Storage Before Use

Keep refrigerated at 36-46°F (2-8°C) in original carton. Protect from light. Do not freeze. If unrefrigerated >30 minutes (up to 24 hours at <77°F/25°C), discard.[1]

What If Something Goes Wrong?

• No click or partial dose: Do not reuse—discard and use a new device.
  
• Accidental activation: Do not recap; dispose safely.
  
• Severe reactions: Stop and contact your doctor. Common issues include flu-like symptoms or skin reactions, manageable with pain relievers or site prep.[1][2]
  
  

Tips from Patients and Providers

Apply ice before/after to numb skin. Inject at consistent times (e.g., evening) to minimize side effects. Track doses in a log or app. Training videos are available from EMD Serono.[2]

[1] Rebif Prescribing Information: https://www.rebif.com/en/us/home.html
[2] Rebif RebiDose Instructions for Use: https://www.rebif.com/-/media/rebif/us/files/rebidose-instructions-for-use.pdf