Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. Painkillers, on the other hand, are medications used to relieve pain. The sources provided do not indicate a direct interaction between Lipitor and painkillers. However, it is important to note that Lipitor has its own set of side effects, which can potentially worsen with the use of painkillers.

According to the National Health Service (NHS) [2], some of the common side effects of Lipitor include headache, muscle pain, and joint pain. Painkillers such as ibuprofen and aspirin, which are commonly used to relieve pain, can also cause headaches, muscle pain, and joint pain as side effects [3]. Therefore, using painkillers while taking Lipitor can potentially increase the risk and severity of these side effects.

Moreover, the article published in the US National Library of Medicine [1] suggests that the use of Lipitor can cause liver damage and muscle problems. Painkillers such as acetaminophen and aspirin can also cause liver damage when taken in large doses or over a long period of time [3]. Therefore, using painkillers while taking Lipitor can potentially increase the risk of liver damage and muscle problems.

In conclusion, while there is no direct interaction between Lipitor and painkillers, it is important to be aware of the potential side effects of both medications. Using painkillers while taking Lipitor can potentially increase the risk and severity of side effects such as headache, muscle pain, joint pain, liver damage, and muscle problems. It is always recommended to consult with a healthcare provider before taking any medications, especially if you are taking multiple medications at the same time.

Sources:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
[2] https://www.nhs.uk/medicines/atorvastatin/side-effects-of-atorvastatin/
[3] https://www.drugs.com/article/pain-relief-medication.html